在兰州大学生物学系，中国医学科学院基础医学研究所细胞生物学室，美国Emory大学细胞与发育生物学专业分别获得学士（1987）、硕士（1990）和博士（1995）学位；在美国Tularik公司完成博士后训练（1995-1997）。曾任美国犹太医学研究中心及科罗拉多大学医学院免疫学系助理教授、副教授（1998-2005），北京大学生命科学学院长江学者特聘教授（2000-2004）。2005-2013年任武汉大学生命科学学院院长，2013年9月任武汉大学副校长，2014年起兼任武汉大学医学研究院院长。

2010年3-5月，在国家教育行政学院第33期中青班学习；2015年3月-2016年1月，在中共中央党校第15期中青年干部培训二班学习。

主要从事免疫相关的细胞信号转导研究。发现了多个抗病毒天然免疫与炎症反应的关键信号和调节蛋白，阐述了这些过程的分子调控机制；发现了新的肿瘤坏死因子家族成员，阐述了其信号转导的分子事件。这些研究为相关感染与免疫性疾病的防治奠定了重要基础。

已在国际刊物发表论文140余篇，被SCI引用10000余次，其中通讯作者论文单篇最高被引用1000余次，第一作者论文单篇最高被引用300余次。

1983-1987 兰州大学生物学系动物学专业，学士

1987-1990 中国医学科学院基础医学研究所细胞生物学研究室，硕士

1992-1995 美国Emory大学细胞及发育生物学专业，博士

1995-1997 美国Tularik公司David Goeddel实验室，博士后

1990-1992 美国密西根大学医学中心，研究助理

1997-1998 美国Magainin製药公司，资深科学家

1998-2003 美国犹太医学研究中心及科罗拉多大学健康科学中心免疫学系，助理教授

2003-2005 美国犹太医学研究中心及科罗拉多大学健康科学中心免疫学系，副教授

2000-2004 北京大学生命科学学院，长江学者计画特聘教授

2005-2013 武汉大学生命科学学院，教授、院长

2013- 武汉大学教授、副校长

2014-武汉大学医学研究院，院长

第十二届全国政协委员，第十三届全国政协常务委员。

主要从事免疫相关的细胞信号转导研究。发现了多个抗病毒天然免疫与炎症反应的关键信号和调节蛋白，阐述了这些过程的分子调控机制；发现了新的肿瘤坏死因子家族成员，阐述了其信号转导的分子事件。这些研究为相关感染与免疫性疾病的防治奠定了重要基础。

已在国际刊物发表论文140余篇，被SCI引用10000余次，其中通讯作者论文单篇最高被引用1000余次，第一作者论文单篇最高被引用300余次。

主持国家科技部973项目、国家自然科学基金重点项目、国家自然科学基金委创新研究群体项目等、国家蛋白质重大科技专项。作为首席科学家承担了2项973/重大科学计画项目，是国家自然科学基金委“抗病毒天然免疫”创新研究群体负责人（获三期延续资助）。

中国科学院院士

开发中国家科学院院士

第十二届全国政协委员

《自然》杰出导师奖

国家自然科学二等奖两次（第一完成人，2010，2015）

中国细胞生物学学会－CST杰出成就奖（首届, 2009）

谈家祯生命科学创新奖

中国教育部自然科学奖一等奖两次(第一完成人, 2006, 2014)

国务院学位委员会第七届学科评议组（生物组）成员

教育部科技委生物与医学学部委员

教育部高等学校生物技术学科教学指导委员会副主任委员

湖北省知识分子联谊会常务副会长

湖北省人民政府参事

湖北省人民政府第五届谘询委员会委员

万人计画科技创新领军人才入选者

十佳全国优秀科技工作者提名奖

中国学位与研究生教育学会研究生教育成果奖二等奖

教育部长江学者计画特聘教授

国家杰出青年基金获得者

新世纪百千万人才工程国家级人选

武汉大学研究生教育杰出贡献奖

武汉大学10大“我心目中的好导师”

美国白细胞生物学学会Dolph Adams奖

美国犹太医学及研究中心首届“杰出青年教授奖”

美国Harmon基金会Harmon关节炎研究奖

美国Ellison医学基金会新学者奖

中国细胞生物学学会副理事长

1.Shu HB,Agranoff A, Nabel EG, Leung K, Neish AS, Collins , Nabel GJ* (1993).Differential regulation of VCAM-1 gene expression by specific NF-kB subunits in endothelial and epithelial cells.Mol Cell Biol13:6283-6289.

2.Shu HB,Li Z, Palacios MJ, Li Q, Joshi HC* (1995). A transient association of g-tubulin at the midbody is required for the completion of cytokinesis during the mammalian cell division.J Cell Sci108: 2955-2962.

3.Shu HB, Joshi HC* (1995). g-Tubulin can both neacleate microtubule assembly and self-assemble into tubular structures in mammalian cells.J Cell Biol130:1137-1147.

4. Hsu H,Shu HB,Pan MG, Goeddel DV* (1996). TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor-1 signal transduction pathways.Cell84:299-308.

5.Shu HB,Takeuchi M, Goeddel DV* (1996). The TNF receptor 2 signal transducers TRAF2 and c-IAP1 are components of the TNF receptor 1 signaling complex.P Natl Acad Sci USA93:13973-13978.

6.Shu HB,Halpins DR, Goeddel DV* (1997). Casperis a FADD and Caspase-related Inducer of Apoptosis.Immunity6:751-763.

7. Yeh WC, Pompa JL, McCurrach ME,Shu HB,Elia AJ, Shahinian A, Ng M, Wajegam A, Mithchell K, El-Deiry WS, Lowe SW, Goeddel DV M,ak TW* (1998). FADD: essential for embryonic development and signaling from some, but not all, inducers of apoptosis.Science279:1954-1958.

8.Shu HB*,Hu WH, Johnson H (1999). TALL-1 is a novel member of the TNF family that is downregulated by mitogens.J Leukocyte Biol65:680-683.

9. Hu WH, Johnson H,Shu HB*(1999). TRAIL signal NF-kB and JNK activation and apoptosis through distinct pathways. J Biol Chem274:30603-30610.

10. Hu WH, Johnson H,Shu HB* (2000). Activation of NF-kB by FADD, Casper and Caspase-8.J Biol Chem275:10838-10844.

11.Shu HB*,Johnson H (2000). BCMA is a receptor for the TNF family member TALL-1.P Natl Acad Sci USA97:9156-9161.

12. Chen D, Li X, Zhai Z,Shu HB*(2002).A novel zinc finger protein interacts with RIP and inhibits TNF- and IL-1-induced NF-kB activation.J Biol Chem.277:15985-15991.

13. Liu Y, Xu L, Opalka N, Kappler J,Shu HB,Zhang G* (2002). Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands.Cell108: 383-394.

14. Wu M, Xu L, Li X, Zhai Z ,Shu HB* (2002). AMID, an AIF homologous mitochondrion-associated protein, induces caspase-independent apoptosis. J Biol Chem277:25617-25623.

15. Xu L,Shu HB*(2002). TRAF3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kB activation and IL10 production.J Immunol169: 6883-6889.

16. Chen D, Xu LG, Chen L, Li L, Zhai Z, andShu HB*(2003). NIK is a component of the EGF/Heregulin receptor signaling complex.Oncogene22:4348-4355.

17. Wu M, Xu L, Zhai Z,Shu HB* (2003). SINK: a p65-interacting protein that negatively regulates NF-kB-dependent transcription. J Biol Chem278:27072-27079.

18. Bin L, Xu L,Shu HB*(2003). TIRP: a novel TIR domain-containing adapter protein involved in toll/interleukin-1 receptor signaling. J Biol Chem27:24526-24532.

19. Bin L, Nielson LD, Liu X, Mason RJ,Shu HB*(2003). Identification of UGRP1 and MARCO as a lung-specific ligand-receptor pair.J Immunol171:924-930.

20. Zhang J, Xu LG, Han KJ,Shu HB*(2004). Identification of a ZU5 and death domain containing inhibitor of NF-kB.J Biol Chem279:17819-17825.

21. Han KJ, Su X, Xu LG, Bin LH, Zhang J,Shu HB*(2004). Mechanisms of TRIF-induced ISRE and NF-kappa B activation and apoptosis pathways.J Biol Chem279:15652-15661.

22. Huang J, Teng L, Li L, Liu T, Li L, Chen D, Xu LG, Zhai Z,Shu HB*(2004).ZNF216 is an A20-like and IKKgamma -interacting inhibitor of NF-kappa B activation.J Biol Chem279:16847-16853.

23. Xu LG, Li LY,Shu HB* (2004). TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis.J Biol Chem279:17278-17282.

24. Wu M, Xu LG, Su T, Huang J, Zhai Z,Shu HB*(2004).AMID is a p53-inducible gene down-regulated in tumors.Oncogene23:6815-6819.

25. Li L, Bin LH, Li F, Liu Y, Chen D, Zhai Z,Shu HB*(2005). TRIP6 is a RIP2-associated common signaling component of multiple NF-kB activation pathways.J Cell Sci118:555-563.

26. Xu LG, Wang YY, Han KJ, Li LY, Zhai Z,Shu HB*(2005). VISA is an adapter protein required for virus-triggered signaling.Mol Cell19:727-740.

27. Huang J, Liu T, Chen D, Zhai Z,Shu HB*(2005).SIKE is an IKK-relative kinases-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.EMBO J24:4018-4028.

28. Zha J, Han K, Xu LG, Zhou Q, Chen D, Zhai Z,Shu HB*(2006). The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IKK family members.J Immunol176:1072-1080.

29. Tian Y, Zhang Y, Zhong B, Wang YY, Diao FC, Wang RP, Zhang M, Chen DY, Zhai ZH,Shu HB*(2007). RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation.J Biol Chem282:16776-16782.

30. Diao F, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Chen D, Zhai Z, Zhong B, Tien P,Shu HB*(2007). Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase.P Natl Acad Sci USA104:11706-11711.

31. Zhang M, Tian Y, Wang RP, Gao D, Zhang Y, Diao FC, Chen DY, Zhai ZH,Shu HB*(2008). Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3.Cell Res18:1096-1014.

32. Zhang B, Huang J, Li HL, Liu T, Wang YY, Waterman P, Mao AP, Xu LG, Zhai Z, Liu D, Marrack P,Shu HB*(2008). GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth.Cell Res18:900-910.

33. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, Lei C, He X, Zhang L, Tien P,Shu HB*(2008). The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation.Immunity29:538-550.

34. Zhong B, Zhang L, Lei Z, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL,Shu HB*(2009). RNF5 negatively regulates virus-induced IRF3 activation via ubiquitination and degradation of MITA.Immunity30:397-407.

35. Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang F,Shu HB*(2009). ISG56 is a negative feedback regulator of virus-triggered signaling and cellular antiviral response.P Natl Acad Sci USA106:7945-7950.

36. Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Yong, Li S, Tien P,Shu HB*(2010). WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kB activation.P Natl Acad Sci USA107:815-820.

37. Li S, Zheng H, Mao AP, Zhong B, Li Y, Liu Y, Gao Y, Ran Y, Tien P,Shu, HB*(2010).Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6.J Biol Chem285:4291-4297.

38. Mao AP, Li S, Zhong B, Li Y, Yan J, Li Q, Teng C,Shu HB*(2010). Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response.J Biol Chem285:9470-9476.

39. Han KJ, Yang Y, Xu LG,Shu HB*(2010).Analysis of a TIR-less splice variant of TRIF reveals an unexpected mechanism of TLR3-mediated signaling.J Biol Chem285:12543-12550.

40. Chen R, Zhang L, Zhong B, Tan B, Liu Y,Shu HB*(2010).The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.Cell Res20:802-811.

41. Zhong B, Zhang Y, Tan B, Liu TT, Wang YY,Shu HB* (2010).The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation.J Immunol184:6249-6255.

42. Lei CQ, Zhong B, Zhang Y, Zhang J,Shu HB*(2010). GSK3bregulates virus-triggered IRF3 activation and cellular antiviral response by promoting TBK1 activation.Immunity33:878-889.

43.Li Q, Yan J, Mao AP, Li C, Ran Y,Shu HB*, Wang YY*(2011). Tripartite motif 8 (TRIM8) modulates TNFa- and IL-1b-triggered NF-kB activation by targeting TAK1 for K63-linked polyubiquitination.P Natl Acad Sci USA108:19341-19346.

44. Ran Y, Liu TT, Zhou Q, Li S, Mao AP, Li Y, Liu LJ, Cheng JK,Shu HB*(2011).SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation.J Mol Cell Biol2:283-292.

45. Liu Y, Song R, Gao Y, Li Y, Wang S, Liu HY, Wang Y, Hu YH,Shu HB*(2012).Protein kinase C-δ negatively regulates T cell receptor-induced NF-kB activation by inhibiting the assembly of CARMA1 signalosome.J Biol Chem287:20081-20087.

46. He X, Li Y, Li C, Liu LJ, Zhang XD, Liu Y,Shu HB*(2012).USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6.J Mol Cell Biol5:39-47.

47. Zhang J, Hu MM, Wang YY,Shu HB*(2012).TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination.J Biol Chem287:28646-28655.

48. Li Y, Chen R, Zhou Q, Xu Z, Li C, Wang S, Mao A, Zhang X, He W,Shu HB*(2012).LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection.P Natl Acad Sci USA109:11770-11775.

49. Wang YY*, Ran Y,Shu HB*(2012).Linear ubiquitination of NEMO brakes the antiviral response.Cell Host Microbe12:129-131.

50. Chen R, Li M, Zhang Y, Zhou Q,Shu HB*(2012).The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation.P Natl Acad Sci USA109:14128-14133.

51. Zheng H, Li Q, Chen R, Zhang J, Ran Y, He X, Li S,Shu HB*(2012).Dual-specificity phosphatase 14 (DUSP14) negatively regulates TNF-aand IL-1-induced NF-κB activation by dephosphorylating the protein kinase TAK1.J Biol Chem288:819-825.

52. Yang Y, Liao B, Wang S, Jin Y,Shu HB*, Wang YY*(2013). The E3 ubiquitin ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation.PNAS110(13):5115-20.

53. Li C, Wei J, Li Y, He X, Zhou Q, Yan J, Zhang J, Liu Y, Liu Y,Shu HB*(2013).Transmembrane protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase-4 activation and apoptosis.J Biol Chem288

54. Lei CQ, Zhang Y, Xia T, Jiang LQ, Zhong B,Shu HB*(2013).FoxO1 Negatively Regulates Cellular Antiviral Response by Promoting Degradation of IRF3.J Biol Chem288:12596-12604.

55. Chen H, Li Y, Zhang J, Ran Y, Wei J, Yang Y,Shu HB*(2013).RAVER1 is a coactivator of MDA5-mediated cellular antiviral response.J Mol Cell Biol5:111-119.

56. Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang XD, Zhong B,Shu HB*(2013). TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3.Proc. Natl. Acad. Sci. USA.111:1509-1514.

57.Yan J, Li Q, Mao AP, Hu MM,Shu HB*(2013). TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination.J. Mol. Cell Biol.6:154-163.

58. Zhang Y, Lei CQ, Hu YH, Xia T, Li M, Zhong B,Shu HB*(2013).Kruppel-like Factor 6 Is a Co-activator of NF-κB That Mediates p65-dependent Transcription of Selected Downstream Genes.J. Biol. Chem289:12876-12885.

59. Qin Y, Zhou MT, Hu MM ,Hu YH, Zhang J, Guo L, Zhong B,Shu HB*(2014). RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms.Plos Pathog10:e1004358.

60. Zhou Q, Lin H, Wang SY, Wang S, Ran Y, Liu Y, Ye W, Xiong XZ, Zhong B,Shu HB*,Wang YY*(2014). The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling.Cell Host Microbe16:450-61.

61. Ran Y,Shu HB, Wang YY*(2014). MITA/STING: A central and multifaceted mediator in innate immune response.Cytokine & Growth F R25: 631-639.

62.Shu HB*, Wang YY*(2014). Adding to the STING.Immunity41:871-3.

63. Hu YH, Zhang Y, Jiang LQ, Wang S, Lei CQ, Sun MS,Shu HB, Liu Y*(2015).WDFY1 mediates TLR3/4 signaling by recruiting TRIF.EMBO REP16: 447-455

64. Wei J, Lian H, Zhong B,Shu HB*(2015). Parafibromin Is a Component of IFN-γ-Triggered Signaling Pathways That Facilitates JAK1/2-Mediated Tyrosine Phosphorylation of STAT1.J Immunol195 : 2870-2878.

65. Hu MM, Xie XQ, Yang Q, Liao CY, Ye W, Lin H,Shu HB*(2015).TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms.J Immunol195: 4415-4425.

66. Luo WW, Li S, Li C , Lian H, Yang Q, Zhong, B,Shu, HB*.iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING.Nat. Immunol.17: 1057-1066.

67. Hu MM, Yang Q, Xie XQ, Liao CY, Lin H, Liu TT, Yin L,Shu HB*. Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus.Immunity.45: 555-569.

68. Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY,Shu HB*(2017).Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.Cell Host Microbe. 21(2):231-243.

69.Hu MM, Liao CY, Yang Q, Xie XQ,Shu HB*(2017).Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5.J Exp Med. 214(4):973-989.

70. Yang Q, Liu TT, Lin H, Zhang M, Wei J, Luo WW, Hu YH, Zhong B, Hu MM,Shu HB*(2017).TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses.PLoS Pathog. 13(9):e1006600.

71. Yan BR, Zhou L, Hu MM, Li M, Lin H, Yang Y, Wang YY,Shu HB*(2017).PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation.PLoS Pathog.13(9):e1006648.

舒红兵主编，《抗病毒天然免疫》，科学出版社，北京，2009

舒红兵主编，《中国学科发展战略·免疫学》，科学出版社，北京，2015