黄芝瑛

研究方向

药物毒理学（肾毒性机制研究及筛选方法的建立等）、药物安全性评价研究与GLP（新药、药用辅料及新材料的评价研究）、动物替代实验方法的研究。

人物经历

1988年6月起，在广州市医药工业研究所从事新药的临床前安全性评价研究工作，参与我国GLP工作的全过程，包括我国GLP规範的起草、修订、建设和运营管理GLP实验室、GLP实验室的认证检查、推广和培训GLP知识，为我国的GLP工作作出了积极的贡献。2005年10月，中山大学以“百人计画”人才引进为药学院研究员、博士生导师。

教授课程

本科：药物毒理学、药物不良反应。研究生：药事法规与新药注册、新药研製原理与技术、药物毒理学进展、药物安全评价与GLP。

社会兼职

现为中山大学药学院药物安全评价中心主任，国家食品药品监督管理局新药及保健食品评审谘询专家，国家发改委药品价格评估专家，中国药学会套用药理专业委员会委员，中国毒理学会药物安全评价专业委员会委员，广东省药理学会常务理事、药物毒理专委会主任委员。

学术成果

科研项目

从1997年9月起，作为主要负责人承担“国家九五攻关项目--筹建国家（广州）新药安全评价研究重点实验室”，并于2000年10月通过国家的验收，成为国内首批“1035工程”中几个从事新药安全评价研究机构之一。从2002年7月起，主持“十五国家重点专项-创新药物与中药现代化”专项中“临床前安全评价关键技术及平台研究”的工作（课题编号：2002AA2Z342H和2004AA2Z3777）。2005年10月通过国家科技部的验收。2008年起，作为课题第二负责人承担科技部“十一五”国家科技支撑计画重点项目药用新辅料临床前安全性评价及药品与包装材料的相容性安全研究(2008BAI55B03)，2011年4月通过验收。国家自然科学基金面上项目：雷公藤甲素影响线粒体通透性转化孔的调控致心肌细胞毒性的机制研究。81473416。2014-18。国家自然科学基金面上项目：雷公藤甲素影响线粒体脂肪酸β-氧化致睪丸支持细胞毒性的机制研究。81773992。2018-2021。广东省2016-18科技套用专项“符合GLP规範的新药安全评价技术创新研究与能力提升”（ 2016B020237003）

代表性论文

Targeting ATG4 in Cancer Therapy. Fu Y,Zhiying Huang, Hong L, Lu JH, Feng D, Yin XM, Li M.Cancers (Basel).2019 May 10;11(5) pii: E649. doi: 0.3390/cancers11050649. Review.
Triptolide induces oxidative damage in NRK-52E cells through facilitating Nrf2 degradation by ubiquitination via the GSK-3β/Fyn pathway. Pan J, Shen F, Tian K, Wang M, Xi Y, Li J,Zhiying Huang*.Toxicol In Vitro. 2019 Aug;58:187-194. doi: 10.1016/j.tiv.2019.03.032. Epub 2019 Mar 26
Triptolide impairs thioredoxin system by suppressing Notch1-mediated PTEN/Akt/Txnip signaling in hepatocytes.Shen F, Xiong Z, Kong J, Wang L, Cheng Y, Jin J,Zhiying Huang*Toxicol Lett.2019 Jan;300:105-115. doi: 10.1016/j.toxlet.2018.10.024. Epub 2018 Oct 28.
Assessment of the Pig-a, micronucleus, and comet assay endpoints in rats treated by acute or repeated dosing protocols with procarbazine hydrochloride and ethyl carbamate.Chen G, Wen H, Mao Z, Song J, Jiang H, Wang W, Yang Y, Miao Y, Wang C,Zhiying Huang*.Wang X*.Environ Mol Mutagen. 2019 Jan;60(1):56-71. doi: 10.1002/em.22227. Epub 2018 Sep 21.
Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo.Fu Y, Hong L, Xu J, Zhong G, Gu Q, Gu Q, Guan Y, Zheng X, Dai Q, Luo X, Liu C,Huang Zhiying, Yin XM, Liu P*, Li M*.Autophagy. 2018 Sep 3. doi: 0.1080/15548627.2018.1517073. [Epub ahead of print]
Triptolide induces p53-dependent cardiotoxicity through mitochondrial membrane permeabilization in cardiomyocytes.Xi Y, Wang W, Wang L, Pan J, Cheng Y, Shen F*,Zhiying Huang*.Toxicol Appl Pharmacol.2018 Sep 15;355:269-285. doi: 10.1016/j.taap.2018.07.011. Epub 2018 Jul 20.
Triptolide-induced mitochondrial damage dysregulates fatty acid metabolism in mouse sertoli cells.Cheng Y, Chen G, Wang L, Kong J, Pan J, Xi Y, Shen F*,Zhiying Huang* Toxicol Lett.2018 Aug;292:136-150. doi: 10.1016/j.toxlet.2018.04.035. Epub 2018 Apr 30.
Triptolide induces mitochondria-mediated apoptosis of Burkitt's lymphoma cell via deacetylation of GSK-3β by increased SIRT3 expression.Kong J, Wang L, Ren L, Yan Y, Cheng Y,Zhiying Huang*, Shen F*.Toxicol Appl Pharmacol. 2018 Mar 1;342:1-13. doi: 10.1016/j.taap.2018.01.011. Epub 2018 Feb 4.
Inhibition of glycogen synthase kinase 3beta ameliorates triptolide-induced acute cardiac injury by desensitizing mitochondrial permeability transition.Wang W, Yang Y, Xiong Z, Kong J, Fu X, Shen F*,Zhiying Huang*Toxicol Appl Pharmacol. 2016 Oct 14. pii: S0041-008X(16)30308-8. doi: 10.1016/j.taap.2016.10.007.
Immunotoxicological Evaluation of Genetically Modified Rice Expressing Cry1Ab/Ac Protein (TT51-1) by a 6-Month Feeding Study on Cynomolgus Monkeys.Tan X, Zhou X, Tang Y, Lv J, Zhang L, Sun L, Yang Y, Miao Y, Jiang H, Chen G,Zhiying Huang*, Wang X*.PLoS One. 2016 Sep 29;11(9):e0163879. doi: 0.1371/journal.pone.0163879. eCollection 201
A high-throughput Bhas 42 cell transformation assay for the determination of the carcinogenicity of three herbal extracts。Jiang Pu, Ying Wang, Naisong Qi, Wenwan Du, Xiaoyan Tan, Gaofeng Chen, Hairuo Wen, Xin Wang, Yanping Hu, Jie Song, Yuwen Qiu, Jinqiang Liang, Xinlu Fu,Zhiying Huang* , Xue Wang*Fundam. Toxicol. Sci.Vol.3, No.4, 157-166, 2016
Resveratrol protects against triptolide-induced cardiotoxicity through SIRT3 signaling pathwayin vivoandin vitro.Yang Y, Wang W, Xiong Z, Kong J, Wang L, Qiu Y, Shen F,Zhiying Huang*Pharmazie. 2016 Sep 1;71(9):514-523. doi: 10.1691/ph.2016.6597
Tanshinone IIA protects against acetaminophen-induced hepatotoxicity via activating the Nrf2 pathway.Wang W, Guan C, Sun X, Zhao Z, Li J, Fu X, Qiu Y, Huang M, Jin J,Zhiying Huang* Phytomedicine. 2016 Jun 1;23(6):589-96. doi: 10.1016/j.phymed.2016.02.022. Epub 2016 Mar 22.
Activation of SIRT3 attenuates triptolide-induced toxicity through closing mitochondrial permeability transition pore in cardiomyocytes.Yang Y, Wang W, Xiong Z, Kong J, Qiu Y, Shen F,Zhiying Huang* Toxicol In Vitro. 2016 Aug;34:128-37. doi: 10.1016/j.tiv.2016.03.020. Epub 2016 Apr 8.
Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity.Jin J, Sun X, Zhao Z, Wang W, Qiu Y, Fu X, Huang M,Zhiying Huang*. Phytomedicine. 2015 Sep 15;22(10):894-901. doi: 10.1016/j.phymed.2015.06.007. Epub 2015 Jul 3.
Autophagy plays an important role in triptolide-induced apoptosis in cardiomyocytes.Zhou J, Xi C, Wang W, Yang Y, Qiu Y,Zhiying Huang* Toxicol Lett.2015 Aug 5;236(3):168-83. doi: 10.1016/j.toxlet.2015.05.013. Epub 2015 May 22
Protective effect of Wuzhi tablet (Schisandra sphenanthera extract) against cisplatin-induced nephrotoxicity via Nrf2-mediated defense response.Jin J, Li M, Zhao Z, Sun X, Li J, Wang W, Huang M,Zhiying Huang*，Phytomedicine. 2015 May 15;22(5):528-35. doi: 10.1016/j.phymed.2015.03.003. Epub 2015 Mar 20
Role of Nrf2 activation and NF-κB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice.Jin J, Xiong T, Hou X, Sun X, Liao J,Zhiying Huang, Huang M, Zhao Z.Food Chem Toxicol.2014 Nov;73:95-104. doi: 10.1016/j.fct.2014.08.009. Epub 2014 Aug 22
Renal interstitial fibrosis induced by high-dose mesoporous silica nanoparticles via the NF-κB signaling pathway.Chen X, Zhouhua W, Jie Z, Xinlu F, Jinqiang L, Yuwen Q,Zhiying Huang*.Int J Nanomedicine. 2014 Dec 18;10:1-22. doi: 10.2147/IJN.S73538. eCollection 2015.
Triptolide-induced oxidative stress involved with Nrf2 contribute to cardiomyocyte apoptosis through mitochondrial dependent pathways.Zhou J, Xi C, Wang W, Fu X, Jinqiang L, Qiu Y, Jin J, Xu J,Zhiying Huang*.Toxicol Lett.2014 Nov 4;230(3):454-66. doi: 10.1016/j.toxlet.2014.08.017. Epub 2014 Aug 26.

黄芝瑛

黄芝瑛

基本介绍