34. Ji, Z., Mei, F.C., Lory, P.L., Gilbertson, S.R., Chen, Y.J.* & Cheng, X.D. Chemical genetic screening of synthetic lethal pancreatic cancer inhibitors using a KRAS-based human pancreatic cancer cell model. Front. Biosci. 2008 In press.
33. Wu, X.R., Liu, N. & Chen, Y.J.* A bacterial enzyme catalyzing double reduction of a β,δ-diketo ester with unprecedented stereoselectivity. Nature Proceedings, 2008, hdl:10101/npre.2008.1697.1
32. Hanson, R.L., Davis, B.L., Chen, Y.J., Goldberg, S.L., Parker, W.L., Tully, T.P., Montana, M.A. & Patel, R.N. Preparation of R-amines from racemic amines with an S-amine transaminase from Bacillus megaterium. Adv. Synth. Catal. 2008, 350(9), 1367-1375.
31. Liu, J.H., Yu, B.Y., Chen, Y.J.* Determination of enantiomeric excess of ethyl 3,5-dihydroxy-6-benzyloxy hexanoate by chiral reverse phase high performance liquid chromatography. Chirality, 2008, 20(1), 51-53.
29. Liu, J.H., Chen, Y.G., Yu, B.Y. & Chen, Y.J* A novel ketone derivative of artemisinin biotransformed by Streptomyces griseus ATCC 13273. Bioorg. Med. Chem. Lett. 2006, 16 (21), 1909-1912.
28. Guo, Z.W., Chen, Y.J., Goswani, A., Hanson, R. H. & Patel, R.N. Synthesis of ethyl and t-butyl(3R,5S)-dihydroxy-6-benzyloxy hexanoates via diastereo- and enantioselective microbial reduction. Tetrahedron: Asymmetry 2006, 17(8), 1589-1602.
27. Steele, C.L., Chen, Y.J., Dougherty, B.A., Li, W., Hofstead, S., Lam, K., Xing, Z. & Chiang, S.J. Purification, functional cloning and characterization of phenylalanine aminomutase: first committed step in Taxol biosynthesis. Arch. Biochem. Biophys. 2005, 438 (1), 1-10.
25. Serrano-Wu, M, St Laurent. D., Chen, Y.J., Huang, S, Lam, K.S., Matson, J.A., Huang, S, Mazzucco, C.E., Stickle, T.M., Tully, T., Wong, H., Vyas, D.M., & Balasubramanian, B.N. Sordarin oxazeoine derivatives as potent antifungal agents. Bioorg. Med. Chem. Lett. 2002, 12 (19), 2757-2760.
24. Canne, L.E., Botti, P., Simon, R.J., Chen, Y.J., Dennis, E.A., & Kent, S.B.H. Chemical protein synthesis by solid phase ligation of unprotected peptide segments J. Am. Chem. Soc. 1999, 121 (38), 8720-8727.
23. Yang, H.C., Mosior, M., Johnson, C., Chen, Y.J., & Dennis, E.A. Group-specific assays that distinguish between the four major types of phospholipase A2. Anal. Biochem. 1999, 269 (2), 278-288.
22. Chen, Y.J., & Dennis, E.A. Expression and characterization of human group V phospholipase A2. Biochim. Biophys. Acta. 1998, 1349 (1), 57-64.
20. Chen, Y.J., & Rosazza, J.P. Oligopeptides as substrates and inhibitors for a new constitutive nitric oxide synthase from rat cerebellum. Biochem. Biophys. Res. Commun. 1996, 224 (2), 303-308.
19. Chen, Y.J., & Rosazza, J.P. Purification and characterization of nitric oxide synthase (NOSNoc) from Nocardia species. J. Bacteriol. 1995, 177 (17), 5122-5128.
18. Chen, Y.J., & Rosazza, J.P. Microbial transformation of ibuprofen by a Nocardia species. Appl. Environ. Microbiol. 1994, 60 (4), 1292-1296.
16. Chiou, G.C. & Chen, Y.J. Effects of antiglaucoma drugs on ocular flow in ocular hypertensive rabbits. J. Ocular. Pharmacol. 1993, 9, 13-24.
15. Chiou, G.C. & Chen, Y.J. Improvement of ocular blood-flow with dopamine antagonists on ocular hypertensive rabbit eyes. Acta. Pharmacologica Sinica, 1992, 13 (6), 481-484.
14. Chiou, G.C. & Chen, Y.J. Effects of dopamine agonist bromocriptine and some dopamine antagonists on ocular flow. J. Ocular. Pharmacol. 1992, 8 (4), 285-294.
13. Chiou, G.C. & Chen, Y.J. Effects of D- and L-isomers of timolol on retinal and choroidal blood flow in ocular hypertensive rabbit eyes. J. Ocular Pharmacol. 1992, 8 (3), 183-190.
12. Chiou, G.C., Shen, Z.F., Zheng, Y.Q. & Chen, Y.J. Enhancement of systemic delivery of peptide drugs via ocular route with surfactants. Drug Develop. Res. 1992, 27 (2), 177-183.
Chen, Y.J. & Liu, N. Olympics may have a negative impact on China’s research. Nature, 2008, 454, 1049.
申请和已授权专利
1. Patel, R.N., Chen, Y.J., Goldberg, S.L., Hanson, R.L., Gill, I., Goswami, A., Tully, T. and Parker, W. Enzymatic preparation of S-amino acid from R,S-amino acid or keto acid. WO 2007/112299A2, US 2007/0231858A1 (2007)
2. Patel, R.N., Chu, L., Johnston, R.M., Guo, Z.W., Chen, Y.J., Goldberg, S.L., Hanson, R.L., Goswami, A. and Katipally, K. Stereoselective reduction process for the preparation of pyrrolotriazine compounds. WO 2006/130657A2 (2006), US 7,393,667 B2 (2008)
3. Rosazza, J.P. and Chen, Y.J. Purifed nitric oxide synthase. US 6,988,446B2 (2006)
4. Steele, C.L., Chen, Y.J., Dougherty, B.A., Hofstead, S., Lam, K., Li, W. and Xing, Z. Compositions and methods for altering biosynthesis of taxanes and taxane-related compounds. WO 2003066871A2 (2003), US 7,273,755B2 (2007)
5. Rosazza, J.P. and Chen, Y.J. Bacterial nitric oxide synthase. US 5,759,835 (1998).
6. Rosazza, J.P. and Chen, Y.J. Purified nitric oxide synthase from rat brain. US 5,856,158 (1998).