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赵英永

2020-05-11 01:53:16分类：首页  /  百科
赵英永

赵英永

男、医学博士、药理学博士后、教授、博士研究生导师。 曾获全国百篇优秀博士学位论文提名奖、入选教育部新世纪优秀人才支持计画、中国药理学会第十五届施维雅青年药理学家奖、中国药学会-赛诺菲青年生物药物奖、第九届陕西省青年科技奖；教育部学科（中药学）评估专家；Scientific Reports和American Journal of Nephrology编委；Pharmacognosy Magazine 编辑；主要从事慢性肾脏病的发病机制及中药抗肾间质纤维化研究。研究内容涉及中药利尿药化学成分的系统研究、利尿和肾保护活药理学和系统生物学等方面。

基本介绍

  • 中文名：赵英永
  • 外文名：Ying-Yong Zhao
  • 国籍：中国
  • 民族：汉
  • 职业：教授
  • 毕业院校：西北大学
  • 代表作品：Trends in Pharmacological Sciences、British Journal of Pharmacology

个人说明

研究概况

男、医学博士、药理学博士后、教授、博士研究生导师。教育部学科（中药学）评估专家、Scientific Reports和American Journal of Nephrology编委、世界中医药学会联合会-临床用药安全研究专业委员会常务理事、中国药理学会肾脏药理专业委员会委员，西北大学从事科研工作。
2010年西北大学获医学博士学位，同年留校从事科研和教学工作，讲师职称；2012年破格晋升副教授职称；2015年特别评审晋升教授职称；2010年和2014年分别获得硕士研究生和博士研究生指导资格；2012年-2014年，第四军医大学药学院从事药理学博士后工作。2014-2015年与University of California Irvine的肾脏病专家Nosratola D. Vaziri教授进行合作研究慢性肾脏病的病理机制及其中药抗肾间质纤维化。
2009年-2018年，在Trends in Pharmacological Sciences、Nature Communications、British Journal of Pharmacology、Nephrology Dialysis Transplantation、Redox Biology、Phytomedicine等国际杂誌发表SCI源期刊论文130篇，其中第1作者和通讯作者论文96篇，H-index为34，全部论文被SCI资料库引用超过3000次和Google scholar引用超过4500次；以第一发明人获授权国家专利6项；主编专着两部。

招生方向

博士后、博士研究生、硕士研究生招生专业：1、中药化学与药理学研究；2、药物代谢与代谢组学研究。

研究领域

天然产物化学；中药药理学；系统生物学

研究方向

利水渗湿类中药的化学成分研究；中药利尿药及治疗慢性肾脏病的药理学研究；慢性肾脏病及其中药防治慢性肾脏病的系统生物学研究

社会兼职

1. 教育部学科（中药学）评估专家
2. 陕西省综合评标评审专家（陕西省发展与改革委员会）
3. 世界中医药学会联合会临床用药安全研究专业委员会 常务理事
4. 中国药理学会肾脏药理专业委员会 委员
American Society of Nephrology Member
5. 期刊任职
Scientific Reports 编委 (影响因子：5.228)
American Journal of Nephrology 编委 (影响因子：2.740)
Pharmacognosy Magazine 编辑 (影响因子：1.069)
Frontiers in Medicine 副主编
Current Metabolomics 编委
药物分析杂誌 编委

获奖

1）2013年，入选教育部“新世纪优秀 人才支持计画”（教育部）
2）2012年，获全国百篇优秀博士学位论文提名奖（教育部）
3）2012年，获第九届陕西省青年科技奖（中共陕西省委组织部、陕西省科学技术协会）
4）2012年，获中国药学会-赛诺菲青年生物药物奖（中国药学会）
5）2011年，获中国药理学会第十五届施维雅青年药理学家奖（ 中国药理学会）

主持科研项目

1）RAS抑制剂茯苓皮三萜酸利尿及抗肾间质纤维化物质基础及作用机制研究，国家自然科学基金
2）基于NF-κB/Nrf2信号通路和脂质组学技术探讨猪苓的利尿物质基础抗肾纤维化的机制，国家自然科学基金
3）猪苓及麦角甾酮对马兜铃酸肾病的保护作用及其机制研究，国家自然科学基金
4）贵细类中药材掺伪造假等检测技术平台，科技部十二五重大新药创製科技重大专项子课题
5）猪苓甾酮研究，科技部十二五重大新药创製科技重大专项子课题
6）茯苓皮的利尿活性成分分离及其防治慢性肾衰竭研究，中国博士后科学基金第七批特别资助基金
7）茯苓皮防治慢性肾病的物质基础及基于代谢组学作用机制，中国博士后科学基金第52批面上资助基金
8）麦角甾酮的合成工艺最佳化及其治疗慢性肾衰竭的药理学研究，陕西省国际科技合作项目
9）治疗慢性肾功能衰竭药物的临床前研究，陕西省科技厅社会发展攻关计画项目

发表SCI论文

  1. Dan-Qian Chen, Gang Cao, Hua Chen, Christos P. Argyopoulos, Hui Yu, Wei Su, Lin Chen, David C. Samuels, Shougang Zhuang, George P. Bayliss, Shilin Zhao, Xiao-Yong Yu, Nosratola D. Vaziri, Ming Wang, Dan Liu, Jia-Rong Mao, Shi-Xing Ma, Jin Zhao, Yuan Zhang, You-Quan Shang, Huining Kang, Fei Ye, Xiao-Hong Cheng, Xiang-Ri Li, Li Zhang, Mei-Xia Meng, Yan Guo, Ying-Yong Zhao*. Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan. Nature Communications2019;10:1476[IF=12.353]
  2. Dan-Qian Chen, Ya-Long Feng, Gang Cao, Ying-Yong Zhao*.Natural products as a source for antifibrosis therapy. Trends in Pharmacological Sciences 2018; 39(11):937-952. [IF=12.108] (Cell子刊，Top期刊)
  3. Ming Wang, Dan-Qian Chen, Lin Chen, Gang Cao, Hui Zhao, Dan Liu, Nosratola D. Vaziri, Yan Guo, Ying-Yong Zhao* Novel inhibitors of the cellular RAS components, Poricoic acids, target Smad3 phosphorylation and Wnt/β-catenin pathway against renal fibrosis. British Journal of Pharmacology 2018;175(13):2689-2708. [IF=6.810] (Top期刊)
  4. Dan-Qian Chen, Gang Cao, Hua Chen, Dan Liu, Wei Su, Xiao-Yong Yu, Nosratola D. Vaziri, Xiu-Hua Liu, Xu Bai, Li Zhang, Ying-Yong Zhao*. Gene and protein expressions and metabolomics exhibit activated redox signaling and wnt/β-catenin pathway are associated with metabolite dysfunction in patients with chronic kidney disease. Redox Biology 2017; 12: 505-521. [IF=7.126](同时入选ESI 0.1%热点论文和ESI 1%高倍引用论文)
  5. Hua Chen, Gang Cao, Dan-Qian Chen, Ming Wang, Nosratola D. Vaziri, Zhi-Hao Zhang, Jia-Rong Mao, Xu Bai, Ying-Yong Zhao*. Metabolomics insights into activated redox signaling and lipid metabolism dysfunction in chronic kidney disease progression. Redox Biology 2016;10:168–178. [IF=7.126](入选ESI 0.1%热点论文)
  6. Dan-Qian Chen, Ya-Long Feng, Lin Chen, Jing-Ru Liu, Ming Wang, Nosratola D. Vaziri, Ying-Yong Zhao*. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/Axl-NF-κB/Nrf2 axis. Free Radical Biology and Medicine 2019;134:484-497. [IF=6.020] (Top期刊)
  7. Lin Chen, Dan-Qian Chen, Jing-Ru Liu, Jun Zhang, Nosratola D. Vaziri, Shougang Zhuang, Hua Chen, Ya-Long Feng, Yan Guo, Ying-Yong Zhao*. Unilateral ureteral obstruction causes gut microbial dysbiosis and metabolome disorders contributing to interstitial fibrosis. Experimental & Molecular Medicine 2019;51:38. [IF=5.583]
  8. Lin Chen, Gang Cao, Ming Wang, Ya-Long Feng, Dan-Qian Chen, Nosratola D. Vaziri, Shougang Zhuang, Ying-Yong Zhao*. The matrix metalloproteinase-13 inhibitor poricoic acid ZI ameliorates renal fibrosis by mitigating epithelial-mesenchymal transition. Molecular Nutrition & Food Research 2019; DOI: 10.1002/mnfr.201900132. [IF=5.151] (Top期刊)
  9. Ming Wang, Dan-Qian Chen, Lin Chen, Hui Zhao, Dan Liu, Zhi-Hao Zhang, Nosratola D. Vaziri, Yan Guo, Ying-Yong Zhao*, Gang Cao. Novel RAS inhibitors poricoic acid ZG and poricoic acid ZH attenuate renal fibrosis via Wnt/β-catenin pathway and targeted phosphorylation smad3 signaling. Journal of Agricultural and Food Chemistry 2018;66(8):1828-1842. [IF=3.412] (Top期刊，同时入选ESI 0.1%热点论文和ESI 1%高倍引用论文)
  10. Ming Wang, Dan-Qian Chen, Min-Chang Wang, Hua Chen, Lin Chen, Dan Liu, Hui Zhao, Ying-Yong Zhao*. Poricoic acid ZA, a novel RAS inhibitor, attenuates tubulo-interstitial fibrosis and podocyte injury by inhibiting TGF-β/Smad signaling pathway. Phytomedicine 2017; 36:243-253. [IF=3.610] (Top期刊)
  11. Dan-Qian Chen, Hua Chen, Lin Chen, Nosratola D. Vaziri, Ming Wang, Xiang-Ri Li, Ying-Yong Zhao*. The Link between phenotype and fatty acid metabolism in advanced chronic kidney disease. Nephrology Dialysis Transplantation 2017;32(7):1154–1166. [IF=4.600](同时入选ESI 0.1%热点论文和ESI 1%高倍引用论文)
  12. Hua Miao, Yu-Hui Zhao, Nosratola D. Vaziri, Dan-Dan Tang, Hua Chen, Han Chen, Mahyar Khazaeli, Mehrdokht Tarbiat-Boldaji, LeiliHatami, Ying-Yong Zhao*. Lipidomics biomarkers of diet-induced hyperlipidemia and its treatment with Poria cocos. Journal of Agricultural and Food Chemistry 2016;64(4):969-979. [IF=3.154](Top期刊)
  13. Hua Chen, Tian Yang, Min-Chang Wang, Dan-Qian Chen, Yang Yang*, Ying-Yong Zhao*. Novel RAS inhibitor 25-O-methylalisol F attenuates epithelial-to-mesenchymal transition and tubulo-interstitial fibrosis by selectively inhibiting TGF-β-mediated Smad3 phosphorylation. Phytomedicine 2018;42:207-218. [IF=3.610] (Top期刊)
  14. Hua Chen, Lin Chen, Dan Liu, Dan-Qian Chen, Nosratola D. Vaziri, Xiao-Yong Yu, Li Zhang, Wei Su, Xu Bai, Ying-Yong Zhao*.Combined clinical phenotype and lipidomic analysis reveals the impact of chronic kidney disease on lipid metabolism. Journal of Proteome Research 2017;16(4):1566-1578. [IF=4.268](入选ESI 1%高倍引用论文)
  15. Yuan‑Yuan Chen, Dan‑Qian Chen, Lin Chen, Jing‑Ru Liu, Nosratola D. Vaziri, Yan Guo, Ying‑Yong Zhao*. Microbiome–metabolome reveals thecontribution ofgut–kidney axis onkidney disease. Journal of Translational Medicine 2019;17:5 [IF=4.197]
  16. Fang Dou, Hua Miao, Jing-Wen Wang, Lin Chen, Ming Wang, Hua Chen, Ai-Dong Wen, Ying-Yong Zhao*.An integrated lipidomics and phenotype study reveals protective effect and biochemical mechanism of traditionally used Alisma orientale Juzepzuk in chronic kidney disease. Frontier in Pharmacology 2018; 9: 53. [IF=4.400]
  17. Yang Sun,Yingyong Zhao*.Enhanced pharmacokinetics and anti-tumor efficacy of PEGylated liposomal rhaponticin and plasma protein binding ability of rhaponticin.Journal of Controlled Release2013;172(1): e82-e83. [IF=8.078]
  18. Ying-Yong Zhao*, Xian-Long Cheng, Feng Wei, Xu Bai, Xiao-Jie Tan, Rui-Chao Lin, Qibing Mei. Intrarenal metabolomic investigation of chronic kidney disease and its TGF-β1mechanism in induced-adenine rats using UPLC Q-TOF/HSMS/MS.Journal of Proteome Research 2013;12(2):692–703 [IF=5.413]
  19. Zhi-Hao Zhang, Hua Chen, Nosratola D. Vaziri, Jia-Rong Miao, Li Zhang, Xu Bai, Ying-Yong Zhao*. Metabolomic signatures of chronic kidney disease of diverse etiologies in the rats and humans. Journal of Proteome Research 2016;15(10):3802-3812. [IF=4.268]
  20. Ying-Yong Zhao*,Nosratola D. Vaziri, Rui-Chao Lin. Lipidomics: new insight into kidney disease. Advances in Clinical Chemistry 2015;68:1-21. [IF=4.302]
  21. Ying-Yong Zhao, Xuefeng Shen, Xu Chao, Charlene C. Ho, Xian-Long Cheng, Yongmin Zhang, Rui-Chao Lin, Ke-Jun Du, Wen-Jing Luo, Jing-Yuan Chen. Ergosta-4,6,8(14),22-tetraen-3-one induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.BBA-General Subjects2011;1810(4):384–390 [IF=5.000]
  22. Ying-Yong Zhao, Xiang-Yang Qin, Xian-Long Cheng, Xue-Ying Liu, Rui-Chao Lin. Rapid resolution liquid chromatography-mass spectrometry and high performance liquid chromatography-fluorescence detection for metabolism and pharmacokinetic studies of ergosta-4,6,8(14),22-tetraen-3-one.Analytica Chimica Acta2010;675(2):199–206 [IF=4.310]
  23. Ying-Yong Zhao*, Hui-Ling Wang, Xian-Long Cheng, Feng Wei, Xu Bai, Rui-Chao Lin, Nosratola D Vaziri. Metabolomics analysis reveals the association between lipid abnormalities and oxidative stress, inflammation, fibrosis, and Nrf2 dysfunction in aristolochic acid-induced nephropathy. Scientific Reports 2015;5:12936 [IF=5.228]
  24. Zhi-Hao Zhang, Nosratola D. Vaziri, Feng Wei, Xian-Long Cheng, Xu Bai, Ying-Yong Zhao*.Anintegrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure. Scientific Reports 2016; 6: 22151 [IF=5.578]
  25. Ting Tian, Hua Chen, Ying-Yong Zhao*. Traditional uses, phytochemistry, pharmacology, toxicology and quality control of Alisma orientale (Sam.) Juzep: A review. Journal of Ethnopharmacology 2014, 2014; 158: 373–387. [IF=3.284]
  26. Zhi-Hao Zhang, Feng Wei, Nosratola D. Vaziri, Xian-Long Cheng, Xu Bai, Rui-Chao Lin, Ying-Yong Zhao*. Metabolomics insights into chronic kidney disease and modulatory effect of rhubarb against tubulointerstitial fibrosis. Scientific Reports 2015;5:14472 [IF=5.228]
  27. Ying-Yong Zhao*, Rui-Chao Lin. Metabolomics in nephrotoxicity. Advances in Clinical Chemistry 2014;65:69-89. [IF=4.302]
  28. Hua Chen, Hua Miao, Ya-Long Feng, Ying-Yong Zhao*, Rui-Chao Lin. Metabolomics in Dyslipidemia. Advances in Clinical Chemistry 2014; 66:101-119. [IF=4.302]
  29. Lin Chen, Wei Su, Hua Chen, Dan-Qian Chen, Ming Wang, Yan Guo, Ying-Yong Zhao*. Proteomics for biomarker identification and clinical application in kidney disease. Advances in Clinical Chemistry 2018; 85: 91–113. [IF=4.722]
  30. Ying-Yong Zhao*. Metabolomics in chronic kidney disease.Clinica Chimica Acta 2013; 422:59-69. [IF=2.850]
  31. Ying-Yong Zhao*, Xian-Long Cheng, Nosratola D. Vaziri, Shuman Liu, Rui-Chao Lin. UPLC-based metabonomics applications for discovering biomarkers of diseases in clinical chemistry. Clinical Biochemistry2014; 47(15):16-26.[IF=2.450]
  32. Ying-Yong Zhao*, Hua Chen, Ting Tian, Dan-Qian Chen, Xu Bai, Feng Wei.A pharmaco-metabonomic study on chronic kidney disease and therapeutic effect of ergone by UPLC-QTOF/HDMS. Plos One 2014; 9(12): e115467. [IF=3.499]
  33. Ying-Yong Zhao*, Xian-long Cheng, Rui-Chao Lin, Feng Wei. Lipidomics applications for diseases biomarker discovery in mammal’s models. Biomarkers in Medicine 2015;9(2):153-168. [IF=3.217]
  34. Ying-Yong Zhao*, Shao-Ping Wu, Shuman Liu, Yongmin Zhang, Rui-Chao Lin. Ultra-performance liquid chromatography-mass spectrometry as a sensitive and powerful technology in lipidomic applications. Chemico-Biological Interactions 2014; 220:181-192. [IF=3.060]
  35. Ming Wang, Lin Chen, Dan Liu, Hua Chen, Dan-Dan Tang, Ying-Yong Zhao*. Metabolomics highlights pharmacological bioactivity and biochemical mechanism of traditional Chinese medicine. Chemico-Biological Interactions 2017; 273:133–141. [IF=3.143]
  36. Ying-Yong Zhao*,Ya-Long Feng, Xu Bai, Xiao-Jie Tan, Rui-Chao Lin, Qibing Mei. Ultra performanceliquid chromatography-based metabonomic study of therapeutic effect of thesurface layer ofPoria cocoson adenine-induced chronic kidney disease provides new insight into anti-fibrosis mechanism.Plos One2013; 8(3): e59617. [IF=4.092]
  37. Lin Chen, Dan-Qian Chen, Ming Wang, Dan Liu, Hua Chen, Fang Dou, Nosratola D. Vaziri, Ying-Yong Zhao*. Role of RAS/Wnt/β-catenin axis activation in the pathogenesis of podocyte injury and tubulo-interstitial nephropathy. Chemico-Biological Interactions 2017;273:56–72. [IF=3.143]
  38. Hua Miao, Ming-Hua Li, Xu Zhang, Sheng-Jun Yuan, Charlene C. Ho, Ying-Yong Zhao*. The antihyperlipidemic effect of Fu-Ling-Pi is associated with abnormal fatty acid metabolism as assessed by UPLC-HDMS-based lipidomics. RSC Advances 2015 5 (79), 64208–64219. [IF=3.289]
  39. Ying-Yong Zhao*, Xian-Long Cheng, Feng Wei. Lipidomics: novel insight into the biochemical mechanism of lipid metabolism and dysregulation-associated disease. Chemico-Biological Interactions 2015; 245: 220-238. [IF=2.577]
  40. Zhi-Hao Zhang, Jia-Rong Mao, Hua Chen, Wei Su, Yuan Zhang, Li Zhang, Dan-Qian Chen, Ying-Yong Zhao*, Nosratola D. Vaziri. Removal of uremic retention products by hemodialysis is coupled with indiscriminate loss of vital metabolites. Clinical Biochemistry 2017; 50(18):1078-1086. [IF=2.434]
  41. Dan-Qian Chen, Hua Chen, Lin Chen, Dan-Dan Tang, Hua Miao, Ying-Yong Zhao*. Metabolomic application in toxicity evaluation and toxicological biomarker identification of natural product. Chemico-Biological Interactions 2016; 252: 114–130 [IF=3.143]
  42. Ying-Yong Zhao*, Ya-Long Feng, Xiao Du, Zhi-Hui Xi, Xian-LongCheng, Feng Wei. Diuretic activity the ethanol and aqueous extracts of thesurface layer ofporia cocosin rat.Journal of Ethnopharmacology2012;144(3):775–778. [IF=3.728]
  43. Ying-Yong Zhao*, Qi Su, Xian-Long Cheng, Xiao-Jie Tan, Xu Bai,Rui-Chao Lin. Pharmacokinetics, bioavailability, and metabolism of rhaponticinin rat plasma by UHPLC–Q–TOF/MS and UHPLC–DAD–MSn.Bioanalysis2012;4(6):713–723. [IF=3.253]
  44. Ying-Yong Zhao*.Traditional uses, phytochemistry, pharmacology, pharmacokinetics and quality control ofPolyporus umbellatus(Pers.) Fries: A review.Journal of Ethnopharmacology2013; 149(1): 35-48. [IF=3.728]
  45. Ying-Yong Zhao*, Xian-Long Cheng, Feng Wei, Xin-Yue Xiao,Rui-Chao Lin. Serum metabonomics study of adenine-induced chronic renal failure rat by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.Biomarkers2012;17(1):48–55. [IF=2.215]
  46. Ying-Yong Zhao*, Jing Liu, Xian-Long Cheng, Xu Bai, Rui-ChaoLin. Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS.Clinica Chimica Acta2012;413(5–6):642–649. [IF=2.850]
  47. Ying-Yong Zhao*, Xian-Long Cheng, Feng Wei, Xu Bai, Rui-ChaoLin.Ultra performance liquid chromatography coupledwith electrospray and atmospheric pressure chemical (ESCi) ionization-quadrupole time-of-flight mass spectrometry with novel mass spectrometryElevated Energy (MSE) data collection technique: Determination and pharmacokinetics, tissue distribution and biliary excretion study of ergone in rat.Journal of Separation Science2012;35(13):1619–1629. [IF=2.733].
  48. Ying-Yong Zhao*,Xian-Long Cheng,Ji-Hong Cui, Xing-Rong Yan, Feng Wei, Xu Bai,Rui-Chao Lin. Effect of ergosta-4,6,8(14),22-tetraen-3-one (ergone) onadenine-induced chronic renal failure rat: A serum metabonomics study based onultra performance liquid chromatography/ high-sensitivity mass spectrometry coupled with MassLynx i-FIT algorithm.Clinica Chimica Acta 2012;413(19–20): 1438–1445. [IF=2.850]
  49. Ying-Yong Zhao*,Xian-Long Cheng, Charlene C. Ho, Feng Wei,Rui-Chao Lin, Yongmin Zhang. Pharmacokinetics of ergosterol in rats using rapid resolution liquid chromatography–atmospheric pressure chemical ionization multi-stage tandem mass spectrometry and rapid resolution liquid chromatography/tandem mass spectrometry.Journal of Chromatography B2011;879(21):1945 –1953. [IF=3.057]
  50. Ying-Yong Zhao*, Rui-Chao Lin. UPLC–MSE application in disease biomarker discovery: the discoveries in proteomics to metabolomics. Chemico-Biological Interactions 2014; 215(1):7-16.[IF=3.060]
  51. Ying-Yong Zhao*, Li Zhang, Jia-Rong Mao, Xiao-Hong Cheng,Rui-Chao Lin. Ergosta-4,6,8(14),22-tetraen-3-one isolated fromPolyporus umbellatusprevents earlyrenal injury in aristolochic acid-induced nephropathy rats.Journal of Pharmacy and Pharmacology2011;63(12):1581–1561.[IF=2.175]
  52. Yingyong Zhao, Lili Wang, Hua Miao, Charlene C. Ho, Jing Li,Xianlong Cheng, Ruichao Lin. LC method for the determination of rhaponticin in rat plasma, faeces and urine for application to pharmacokinetic studies.Chromatographia2011;73(5–6):599–603. [IF=1.195]
  53. Ying-Yong Zhao, Xian-Long Cheng, Yongmin Zhang, Xu Chao,Rui-Chao Lin. A fast and sensitive HPLC-MS/MS analysis and preliminary pharmacokinetic characterization of ergone in rats.Journal of Chromatography B2010;878(1):29–33. [IF=2.971]
  54. Ying-Yong Zhao, Xu Chao, Yongmin Zhang, Rui-Chao Lin.Cytotoxic steroids fromPolyporus umbellatus.Planta Medica2010;76(15):1755–1758. [IF=2.369]
  55. Ying-Yong Zhao, Xian-long Cheng, Yongmin Zhang, Ye Zhao,Rui-chao Lin. Simultaneous determination of eight major steroids fromPolyporus umbellatusby high-performance liquid chromatography coupled with mass spectrometry detections.Biomedical Chromatograph2010; 24(2):222–230. [IF=1.545]
  56. Ying-Yong Zhao, Xiang-Yang Qin, Yongmin Zhang, Rui-chao Lin,Xiao-Ye Li. Quantitative HPLC method and pharmacokinetic studies ofergosta-4,6,8(14),22-tetraen-3-one, a natural product with diuretic activity fromPolyporus umbellatus.Biomedical Chromatography2010;24(10):1120–1124. [IF=1.545]
  57. Ying-Yong Zhao, Xian-long Cheng, Ren-ming Xie, Xu Chao,YongminZhang, Rui-chao Lin. Bioactivity-directed isolation, identification of diuretic compounds fromPolyporus umbellatus.Journal ofEthnopharmacology2009;126(1):184–187. [IF=3.728]
  58. Ying-Yong Zhao, Yong-min Zhang, Rui-chao Lin. An expeditious HPLC method to distinguishAconitum kusnezoffiifrom related species.Fitoterapia2009;80(6):333–338. [IF=2.139]
  59. Ying-Yong Zhao, Ye Zhao, Yong-min Zhang, Rui-chao Lin.Qualitative and quantitative analysis of diuretic component ergone inPolyporus umbellatusby HPLC with fluorescence detection and HPLC-APCI-MS/MS.Pharmazie2009;64(6):366–370. [IF=0.812]
  60. Ying-Yong Zhao, Libin Yang, Minchang Wang, Lili Wang ,Xian-long Cheng, Rui-chao Lin. 1β-hydroxylfriedelin, a new natural pentacylic triterpene from the sclerotia ofPolyporus umbellatus.Journal of Chemical Research2009;11:699–701. [IF=0.550]
  61. Ying-Yong Zhao, Xiang-Yang Qin, San-Ping Chen, Yongmin Zhang,Rui-Chao Lin. Crystal and molecular structure of rhaponticin fromRheum hotaoense.Journal of Chemical Crystallography2011;41(3):409–414. [IF=0.566]
  62. Ying-Yong Zhao*, Xuefeng Shen, Xian-Long Cheng, Feng Wei, XuBai, Rui-Chao Lin. Urinary metabonomics study on the protective effects of ergosta-4,6,8(14),22-tetraen-3-one on chronic renal failure in rats using UPLC Q-TOF/MS and a novel MSEdata collection technique.Process Biochemistry2012;47(12):1980–1987. [IF=3.225]
  63. Ying-Yong Zhao*, Xian-Long Cheng, Feng Wei, Xu Bai, Rui-ChaoLin.Application of faecal metabonomics on an experimentalmodel of tubulointerstitial fibrosis by ultra performance liquid chromatography/ high-sensitivity mass spectrometry with MSEdata collection technique.Biomarkers2012;17(8):721–729.[IF=2.215]
  64. Ying-Yong Zhao*, Li Zhang, Ya-Long Feng, Dan-Qian Chen, Zhi-HuiXi, Xiao Du, Xu Bai, Rui-Chao Lin. Pharmacokinetics of 2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside inrat using ultra-performance LC-quadrupole TOF-MS.Journal of Separation Science2013; 2013;36(5):863 –871. [IF=2.733]
  65. Ying-Yong Zhao*, Xian-Long Cheng, Feng Wei, Xiao-Qiang Han,Xin-Yue Xiao, Rui-Chao Lin. Pharmacokinetics,bioavailability, and metabolismof 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucosidein rats by ultra performance liquid chromatography–quadrupole time-of-flightmass spectrometry and high performance liquid chromatography-ultraviolet detection.Journal of Liquid Chromatography & Related Technologies2013;36(6):717–730. [IF=0.706]
  66. Ying-Yong Zhao*, Li Zhang, Feng-Ya Long,Xian-Long Cheng, Xu Bai, Feng Wei, Rui-Chao Lin.UPLC-Q-TOF/HSMS/MS-based metabonomics for adenine-induced changes in metabolic profiles of rat faeces and intervention effects of ergosta-4,6,8(14),22-tetraen-3-one.Chemico-Biological Interactions2013;301(1–3):31–38. [IF=3.060]
  67. Ying-Yong Zhao*, Ping Lei,Dan-Qian Chen, Ya-Long Feng, Xu Bai.Renal metabolic profiling of early renal injury and renoprotective effects ofporia cocosepidermis using UPLCQ-TOF/HSMS/MS.Journal of Pharmaceutical and Biomedical Analysis2013; 81–82(1):202–209. [IF=2.967]
  68. Ying-Yong Zhao*,Hai-Tao Li, Ya-Long Feng,Xu Bai, Rui-Chao Lin.Urinary metabonomic study of the surface layerofporia cocosas an effective treatment for chronic renal injury in rats.Journal of Ethnopharmacology 2013;148(2):403-410. [IF=3.728]
  69. Ying-Yong Zhao*, Ting Tian, Hua Chen, Jia-Rong Mao, Xu Bai, Xiao-Hong Cheng, Xin-Yue Xiao. Urinary metabolomics and biomarkers of aristolochic acid nephrotoxicity by UPLC-QTOF/HDMS. Bioanalysis 2015; 7(6):685-700. [IF=3.027]
  70. Ying-Yong Zhao*, Ya-Long Feng, Ren-Ming Xie, Rui-Chao Lin.Polyporus umbellatus(Pers.) Fries:Traditional uses, phytochemistry, pharmacology, pharmacokinetics and qualitycontrol: A review.Acta Pharmacologia Sinica2013; 34:35. [IF=2.083]
  71. Yang Sun,Yingyong Zhao (co-first author),Guobo Li, Shengyong Yang, Xiaoyun Hu, Jun Fan. Studies of Interaction between Ergosta-4,6,8(14),22-tetraen-3-one (Ergone) and human serum albumin bymolecular spectroscopy and modeling.Journal of the Chinese Chemical Society-Taipei2011;58(5):602–610. [IF=0.678]
  72. Dan-Qian Chen, Ya-Long Feng, Ting Tian, Xiang-Yang Qin,Ying-Yong Zhao*. Cloud-point extraction combined with liquid chromatography for determination of ergosterol, a natural product with diuretic activity, in rat plasma, urine and faeces.Journal of Analytical Methods in Chemistry2013; 2013: 479056. [IF=0.565]
  73. Dan-Qian Chen, Ya-Long Feng, Ting Tian, Hua Chen, Lu Yin, Ying-Yong Zhao*, Rui-Chao Lin. Diuretic and anti-diuretic activities of fractions of Alismatis Rhizoma. Journal of Ethnopharmacology 2014;157:114–118. [IF=3.728]
  74. Yang Sun, Chun-Mei Hu, Guo-Bo Li, Sheng-Yong Yang, Lu-Sha Liu, Chun-Lei Tan, SongWei, Xaio-Yun Hu,Ying-Yong Zhao*,Jun Fan. Studies on the binding of iosalantolactone to human serum albumin by molecular spectroscopy and modeling.Indian Journal of Chemistry2011;50A:1477–1484. [IF=0.891]
  75. Lushu Liu, Yang Sun, Song Wei, Xiaoyun Hu,YingyongZhao*, Jun Fan. Solvent effect on the absorption and fluorescence of ergone:Determination of ground and excited state dipole moments.Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2012;86:120–123. [IF=2.098]
  76. Yang Sun,Yingyong Zhao*. Enhanced pharmacokinetics and anti-Tumor efficacy of PEGylated liposomal rhaponticin andplasma protein binding ability of rhaponticin.Journal of Nanoscience and Nanotechnology2012;12(10):7677–7684. [IF=1.563]
  77. Yang Sun, Zhen Ji,Yingyong Zhao*, XuhuaLiang, Xiaoyun Hu, Jun Fan. Enhanced distribution and anti-tumor activity ofergosta-4,6,8(14),22-tetraen-3-one by PEG liposomalization.Journal ofNanoscience and Nanotechnology2013;13(2):1435–1439. [IF=1.563]
  78. Xuhua Liang, Yang Sun, Wenyuan Zeng, Lusha Liu, Xuan Ma,Yingyong Zhao*, Jun Fan. Synthesis and biological evaluation of afolate-targeted rhaponticin conjugate.Bioorganic & Medicinal Chemistry2013;21(1):178–185. [IF=2.554]
  79. Xuhua Liang, Yang Sun, Lusha Liu, Xuan Ma, Xiaoyun Hu, Jun Fan,Yingyong Zhao*. Folate-functionalized nanoparticles for controlled ergosta-4,6,8(14),22-tetraen-3-one delivery.International Journal of Pharmaceutics2013;441(1–2):1–8. [IF=3.785]
  80. Chang Wang, Mei-Xia Meng, Xu-Lei Tang, Ke-Ming Chen, Li Zhang, Wei-Ning Liu,Ying-Yong Zhao*The proliferation, differentiation and mineralization effects of puerarin on osteoblastsin vitro.Chinese Journal of Natural Medicines 2014;12(6):444-450.
  81. Ya-Long Feng, Ping Lei, Hua Chen, Ting Tian, Lu Yin, Dan-Qian Chen, Qibing Mei,Ying-Yong Zhao*, Rui-Chao Lin. Diuretic activity of some fractions of the epidermis ofPoria cocos.Journal of Ethnopharmacology 2013, 150(3):1114-1118. [IF=3.728]
  82. Ya-Long Feng, Hua Chen, Ting Tian, Dan-Qian Chen, Ying-Yong Zhao*, Rui-Chao Lin. Diuretic and anti-diuretic activities of the ethanol and aqueous extracts of Alismatis Rhizoma. Journal of Ethnopharmacology 2014, 154(2):386-390. [IF=3.728]
  83. Hua Chen, Lin Chen, Dan-Dan Tang, Dan-Qian Chen, Hua Miao, Ying-Yong Zhao*, Shuang-Cheng Ma*.Metabolomics reveals hyperlipidemic biomarkers and antihyperlipidemic effect of Poria cocos. Current Metabolomics 2016;4(2):104-115.
  84. Hua Miao, Li Zhang, Dan-Qian Chen, Hua Chen, Ying-Yong Zhao*, Shuang-Cheng Ma. Urinary biomarker and treatment mechanism of Rhizoma Alismatis on hyperlipidemia. Biomedical Chromatography 2017;31(4):e3829. [IF=1.729]
  85. Ying-Yong Zhao*, Xian-Long Cheng, Rui-Chao Lin. Lipidomics applications for discovering biomarkers of diseases in clinical chemistry.International review of cell and molecular biology 2014; 313: 1-26. [IF=4.970]
  86. Chung-I Li, David C Samuels, Ying-Yong Zhao, Yan Guo. Power and sample size calculations for high throughput sequencing based experiments. Briefings in Bioinformatics 2017; doi: 10.1093/bib/bbx061. [IF=8.399]
  87. Pan Zhang, Brian D. Lehmann, David C. Samuels, Shilin Zhao, Ying-Yong Zhao, Yu Shyr, Yan Guo. Estimating relative mitochondrial DNA copy number using high throughput sequencing data. Genomics 2017;109(5-6):457–462. [IF=2.801]
  88. Nosratola D. Vaziri, Shuman Liu, Seyed HFarzane, SohrabNazertehrani, MahyarKhazaeli, Ying-Yong Zhao. Dose-dependent deleterious and salutary actions of Nrf2 inducer, dh404, in chronic kidney disease. Free Radical Biology and Medicine 2015; 86: 374–381. [IF=5.710]
  89. Zhi-Hao Zhang,Ying-Yong Zhao, Xian-long Cheng, Zhong Dai, Chao Zhou, Xu Bai, Rui-Chao Lin. General toxicity ofPinellia ternate(Thunb.) Berit. in rat: A metabonomic method for profiling of serum metabolic changes.Journal of Ethnopharmacology 2013;149(1):303–310. [IF=3.728]
  90. Zhi-Hao Zhang,Ying-Yong Zhao, Xian-longCheng, Rui-Chao Lin, Zhong Dai, Chao Zhou. Metabonomic study of biochemical changes in the rat urine induced byPinelliaternata(Thunb.) Berit.Journal of Pharmaceutical and Biomedical Analysis2013;85(1):186–193. [IF=2.967]
  91. Li Yan, Fan Song, Hua Li, Yao Li, Jie Li, Qiao-yan He, Zhang Di, Fang Wang, Meng Zhang, Hang Zhao, Tian Feng, Ying-Yong Zhao*, Si-wang Wang.Submicron emulsion of cinnamaldehyde ameliorates bleomycin-induced idiopathic pulmonary fibrosis via inhibition of inflammation, oxidative stress and epithelial-mesenchymal transition.Biomedicine & Pharmacotherapy 2018; 102: 765-771. [IF=3.457]
  92. Lin Chen, Tian Yang, De-Wen Lu, Hui Zhao, Ya-Long Feng, Hua Chen, Dan-Qian Chen, Nosratola D Vaziri, Ying-Yong Zhao*. Central role of dysregulation of TGF-β/Smad in CKD progression and potential targets of its treatment. Biomedicine & Pharmacotherapy 2018; 101: 670–681. [IF=2.759]
  93. Lusha Liu, Jun Fan, Chunmei Hu, Yang Sun, Xiaoyun Hu,Yingyong Zhao, Song Wei, Xuhua Liang. Studies on the Interaction between tubeimoside II and human serum albumin by spectroscopic methods.Acta Chimica Sinica2011;69(21):2589–2596. [IF=0.533]
  94. He-He Hu, Dan-Qian Chen, Yan-Ni Wang, Ya-Long Feng, Gang Cao, Nosratola D. Vaziri, Ying-Yong Zhao*. Newinsights into TGF-β/Smad signaling in tissue fibrosis. Chemico-Biological Interactions 2018; 292: 76–83. [IF=3.143]
  95. Xu Chao, Feng Shi,Ying-Yong Zhao, Ke Li, Ming-Li Peng, Chao Chen, Ya-Li Cui. Cytotoxicity of Fe3O4/Au composite nanoparticles loaded with doxorubicin combined with magnetic field.Pharmazie2010;65(7):500–504. [IF=0.869]
  96. Sui-Hong Yan,Ying-Yong Zhao, Hai-Song Zeng,Yongmin Zhang, Rui-Chao Lin, Wen-Ji Sun. Chemical composition and antioxidant activities of extracts fromApocyni Veneti Folium.Natural Products Research2012;26(7):600–608. [IF=0.906]
  97. Ying-Yong Zhao, Shuang-Qing Zhang, Feng Wei, Yu-Ming Fan, Feng Sun, Shuhua Bai. Quality Control of Natural Product Medicine and Nutrient Supplements 2014.Journal of Analytical Methods in Chemistry2013;2014:109068. [IF=0.948]
  98. Shuang-Qing Zhang, Feng Wei, Yu-Ming Fan, Feng Sun,Ying-Yong Zhao*, Shuhua Bai. Quality Control of Natural Product Medicine and Nutrient Supplements.Journal of Analytical Methods in Chemistry2013;2013:182573. [IF=0.948]

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