1995年6月于第三军医大学获得病理与病理生理专业硕士学位,2000年6月于第三军医大学获得病理与病理生理专业博士学位;2000年8月至2002年8月于复旦大学遗传学研究所做博士后;2002年9月至2005年1月于复旦大学遗传学研究所任副教授;2005年1月至2006年5月在University of British Columbia 做博士后。
近期发表部分文章: 1. Chen JZ, Ji CN, Xu GL, Pang RY, Yao JH, Zhu HZ,, Xue JL, Jia W. DAXX interacts with phage {Phi}C31 integrase and inhibits recombination. Nucleic Acids Res. 20062006; 34, 6298-6304.
2. Zhu HZ,*, Wang W, Feng DM, Sai Y, Xue JL. Conditional gene modification in mouse liver using hydrodynamic delivery of plasmid DNA encoding Cre recombinase. FEBS Lett. 2006 ,580,4346-4352
3. Feng D, Chen J, Yue Y, Zhu H, Xue J, Jia WW. A 16bp Rep Binding Element is Sufficient for Mediating Rep-dependent Integration into AAVS1. J Mol Biol. 2006,358,38-45。
4. W.H.Pi, H.Z.Zhu,, S.S.Zhang, S.R.Liu and J.L.Xue. The effect of estrous ewe serum and heparin on in vitro fertilization and subsequent embryonic development in sheep. Small Ruminant Research, 2006,63,226-232。
5. Zhu HZ,*, Wang Y, Cheng JQ , Chen GX, Xue JL. Transgenic mice expressing Hepatitis B Virus X-protein are more susceptible to carcinogen-induced hepatocarcinogenesis. Experimental Molecular Pathology.2004, Vol 76(1) pp 44-50。
6. Chen HY, Zhu HZ,, Lu B, Xi X, Yao JH, Sheng Q and Xue JL. Enhancement of naked FIX cDNA expression by chlorquine in vivo. Acta Pharmacologica Sinica. 2004, 25(5),570-575。
7. Chen XG*, Zhu HZ,*, Gong JL, Li F, Xue JL. The efficient delivery of human clotting factor IX after injection of lentiviral vectors in utero. Acta Pharmacologica Sinica. 2004,25(6)789
8. Zhu HZ,, Chen XG, Li F, Gong JL & Xue JL Expression of human clotting factor IX mediated by recombinant lentiviral vector incultured cells and hemophilia B mice. Chinese Science Bulletin 2004。 48 (20)2196-2200.
9. Zhu HZ,, Cheng JQ,Chen GX, Xue JL.Generation and characterization of the transgenic mice expressing a Tamoxifen-inducible Cre-fusion protein specifically in the mouse liver。World J Gastroenterology.2003,9(8),1844-1847.
10. Zhu HZ,, Cao YY, Cheng GX, Xue JL.Conditional gene activation in cultured hepatocytes using a ligand-dependent chimeric Cre recombinase. ACTA BIOCHIMICA ET BIOPHYSICA SINICA , 2003,23(5)436-440) 。
11. Zhu HZ,, Cheng GX ,Chen JQ, Kuang SY, Cheng Y, Zhang XL, LI HD, Xu SP, Shi JQ, Qian GX, Gu JR. Preliminary study on the production of transgenic mice harboring hepatitis B Virus X gene. World J Gastroenterology, 1998,4(6),536-539.
12. Zhu HZ,, Zhang XL, Chen YS. Expression of GST-P mRNA in hepatic preneoplastic lesions in rats, World J Gastroenterology ,1998,4(1),38-40。
13. Wang W, Zhu HZ,, Xue JL。RNAi as a gene therapy approach。PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 31 (7): 590-595 JUL 2004。
14. Zhu HZ,,, Shi JQ。Strategies and applications of the Cre/LoxP system in transgenic mice. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 27 (3): 235-238 JUN 2000。